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IPFS

Explanation of a retroviruses

Written by Dr. Judy Mikovits Subject: Science, Medicine and Technology

Information on Retroviruses...

helix..watch about xmrvs..

Explanation of a retroviruse…use the cell read to make its own DNA and inserted into your DNA ..make you a different species..factory and make more factory..
makes you into something else! body sees

retroviruses…live forever..guinea pig to see what happens...
fundamental concept of we are just lab rats

How to treat issues with retroviruses....Baicalin. Scutelaria…liftmode.com <http://liftmode.com/>..amazon

Cistus incanus (Pandalis)

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Reference Article

Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins

http://www.nature.com/articles/srep20394

Abstract

Novel therapeutic options are urgently needed to improve global treatment of virus infections. Herbal products with confirmed clinical safety features are attractive starting material for the identification of new antiviral activities. Here we demonstrate that Cistus incanus (Ci) herbal products inhibit human immunodeficiency virus (HIV) infections in vitro. Ci extract inhibited clinical HIV-1 and HIV-2 isolates, and, importantly, a virus isolate with multiple drug resistances, confirming broad anti-HIV activity. Antiviral activity was highly selective for virus particles, preventing primary attachment of the virus to the cell surface and viral envelope proteins from binding to heparin. Bioassay-guided fractionation indicated that Ci extract contains numerous antiviral compounds and therefore has favorably low propensity to induce virus resistance. Indeed, no resistant viruses emerged during 24 weeks of continuous propagation of the virus in the presence of Ci extracts. Finally, Ci extracts also inhibited infection by virus particles pseudotyped with Ebola and Marburg virus envelope proteins, indicating that antiviral activity of Ci extract extends to emerging viral pathogens. These results demonstrate that Ci extracts show potent and broad in vitro antiviral activity against viruses that cause life-threatening diseases in humans and are promising sources of agents that target virus particles.

Introduction

Virus infections pose serious threats to human health on a global scale. The human immunodeficiency virus (HIV) causes chronic, life-long infection that leads to AIDS without antiretroviral treatment. Over 35 million individuals are living with HIV/AIDS and the pandemic has remained among the 10 leading global causes of death for over a decade, especially in low-income countries1. Emerging viruses like the Ebola virus (EBOV) can cause an acute disease with symptoms appearing 2–21 days after infection and a high risk of death (average mortality rate ~50%) (For summary of current knowledge regarding Ebola virus disease see2). EBOV can cause sudden outbreaks, like the one that flared up in May 2014 in West Africa (Guinea, Liberia and Sierra Leone). Next to the death of more than 10 000 individuals, this outbreak placed an additional heavy burden on countries already weakened by lack of resources and long periods of conflict and instability and lead to breakdown of local health care systems.

There is a strong need for the development of novel antiviral agents for treatment of life-threatening viral infections. Despite the availability of a number of approved drugs for treatment of HIV/AIDS (≥253), current anti-HIV therapies would still benefit from various improvements. Limitations include the high risk of emergence of resistant viruses, poor penetration of virus sanctuaries like the central nervous system, adverse effects, especially in the context of long-term therapy, and incomplete access to affordable therapies in resource-limited areas4,5,6,7. Furthermore, the majority of these drugs block post-entry steps of the virus replication cycle and attack only a few viral targets, such as the viral reverse transcriptase, protease or integrase3.

In contrast to HIV/AIDS, no approved drugs are currently available to combat EBOV infections. The lack of targeted antiviral therapies is one of the most frightening aspects of managing EBOV outbreaks.

Plant-derived natural products play a significant role for medical treatments8,9. Herbal extracts represent the primary form of health care for a major proportion of the world's population10 and are an important source of single-molecule drug leads. A prominent example is the anti-malaria activity of Artimisia annua11 discovered by YouYou Tu, recipient of the 2015 Nobel Prize for Physiology and Medicine12.

Antiviral activities have been reported for numerous medicinal plants9,13. However, their implementation as herbal antiviral medicines requires in-depth research of their efficacy, safety, composition and mechanisms-of-action14. Data for clinical safety and for biological activities are available for a few herbal extracts, some of which are sold as over-the-counter medicines in Europe. We seek to investigate the antiviral activities of these clinically evaluated herbal medicines against major human viral pathogens like HIV-1 as an initial step for the identification of new sources of antiviral agents. This approach is supported by our recent demonstration of anti-HIV-1 activity of extracts of Pelargonium sidoides15, licensed in Germany as the herbal medicine Umckaloabo®.

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www.universityofreason.com/a/29887/KWADzukm