"We are very excited that, unlike Columbus, we found what we were looking for: well-known enzymes that bind to RNA," says Matthias Hentze, who led the study at EMBL with Jeroen Krijgsveld. "But we never thought there was still so much unexplored territory, so many of these RNA-binding proteins to be discovered."
Almost 50 of the new proteins Hentze and Krijgsveld found are encoded by genes known to be mutated in patients suffering from a variety of diseases, from diabetes and glaucoma to prostate and pancreatic cancers. This finding opens new avenues for researchers studying these disorders. It raises the possibility that such conditions could be caused by a malfunction not in the protein's previously established function, but in its potential role in RNA control.