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Chemotherapy obsolete? "Ceramide nanoliposome" uses liposomal delivery to target...


(Natural News) Penn State researchers have developed a new compound, called ceramide nanoliposome, that has the potential to replace radiation and chemotherapy in the future. This new drug is able to smart kill tumors, meaning it targets and destroys cancer cells while leaving healthy cells unharmed.

In 2005, James Adair, professor of materials science and engineering, biomedical engineering, and pharmacology and partner Mark Kester, director of NanoStar Institute at the University of Virginia and former professor of pharmacology at Penn State College of Medicine in Hershey, founded the biopharmaceutical company Keystone Nano with the goal of gaining the U.S. Food and Drug Administration's (FDA) approval for nanoscale biomedical products, the Penn State News website reported.

After years of research and testing, the FDA finally gave the green light to begin phase one human clinical trials to assess the use of ceramide nanoliposome as a possible cancer treatment. With the trials, Keystone Nano hopes to find safe dosing levels and examine the compound's efficacy as an alternative cancer-fighting therapy.

Providing a greater window of treatment and no side-effects

Ceramide has previously been shown to possess strong anti-cancer properties. Its delicate structure, however, has stopped other researchers from using it in clinical tests to treat cancer. The Penn researchers used nanotechnology to coat ceramide in a fatty lipid layer to improve its stability in the body. This new and improved compound targets tumor cells, penetrates the cellular lining, and deposes its chemotherapeutic cargo in the cancer cell.

"Ceramide is a bioactive lipid that selectively kills cancer cells. At equal dosing, normal cells go to sleep, cancer cells die," explained Kester. "The problem is it precipitates. It falls out of solution. The only way to deliver it is to turn it into a nanoformulation, which is our intellectual property. Think of it as a very small FedEx truck that delivers on time, all the time but only to the cancer cells."

Thanks to the extra protective layer, or coating, weaved around the compound, ceramide has been found to have a much greater window of effectiveness compared to current chemotherapy treatments. A window of treatment is the gap between the dosage at which a drug becomes effective and when it becomes harmful to the patient. Therefore, drugs with a larger window or gap will have fewer risks.

Though clinical trials in humans will provide more information and proof of its beneficial effects, dozens of preclinical animal tests have shown that ceramide nanoliposomes are harmless to healthy cells and remain in the body attacking cancer cells for more than a day.