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Is Cancer Caused By Unbalanced Chromosomes Rather Than Gene Mutations?


What causes cancer?  Or more important, what un-causes cancer?

In widespread circulation on the worldwide web today (March 7) is investigative reporter Jon Rappoport's coverage of the work of cancer researcher David Rasnick PhD.  Rasnick proposes cancer does not emanate from accumulated gene mutations as commonly believed but rather from unbalanced chromosomes.  Dr. Rasnick attempts to raise funds to complete his 2nd edition book on this topic (Precarious Balance: What Cancer Really is)

The theory of chromosomal imbalance and cancer may be new to reporter Rappoport, but not to the cancer research world.  One might get the misimpression Dr. Rasnick is the originator of this theory after reading Rappoport's report and visiting Dr. Rasnick's website.  The modern chromosomal theory of cancer has been postulated from University of California, Berkeley genetics researcher Peter Duesberg, as explained in his paper entitled CHROMOSOMAL CHAOS AND CANCER, published in Scientific American in 2007.

Duesberg gives credit to German biologist Theodor Boveri who in 1888 first advanced the theory that cancer stems from chromosomal instability.  For the scientific-savvy reader a more technical paper by Dr. Duesberg on this subject was published in 2006. [Contributions in Microbiology 2006]

How chromosome imbalance leads to cancer

For background information, living cells divide (mitosis) and produce daughter cells.  This is accomplished in what is called the CELL CYCLE.

Recognize that some cells don't rapidly divide and make copies, like brain cells and heart muscle cells (we only make a few new brain and heart muscle cells over a period of many years).  Therefore, there are far fewer tumors in the heart and brain.  If cell turnover were fast in the brain, memory would be erased.  If cell turnover were fast in the heart the muscle would be weak.  Cells in the skin and digestive tract and back of the eyes rapidly renew to repair damage from solar radiation, high temperature (hot foods) and exposure to germs (our foods are not sterile).  Tumors grow fast in the skin and the digestive tract because they have fast cell turnover (renewal) rates.

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