Byrne is an American entrepreneur and e-commerce pioneer. In 1999, Byrne launched Overstock after leading two smaller companies, including one owned by Warren Buffett's Berkshire Hathaway. In 2002, Byrne took Overstock.com public. Since its initial public offering (IPO), Overstock.com has increased revenue to almost $1.8 billion while achieving profitability in 2009. In January 2014, Overstock.com became the first major retailer to accept bitcoin.

In Decemeber 2017, Byrne teamed with world-renowned economist Hernando de Soto to develop a blockchain-based property registry system to ensure the property rights of billions of people in the developing world. The goal is to promote the interests of people who are currently operating extra-legally, as well as multinational corporations who are trying to cooperate with local owners.

In an interview with FOX Business, Byrne, who has been a long-time advocate for bitcoin, said that blockchain technology can lift billions out of poverty. He added that they are looking for suitors who may be interested in their multi-billion dollar project.