IPFS News Link • Science

Sugar-coated antibodies cross blood-brain barrier to fight Alzheimer's

• arclein

Thinking the issue might have to do with the fact that the amyloid-fighting antibodies may be too large to pass through the blood-brain barrier, researchers at Tokyo Medical and Dental University hid smaller portions of them inside round nanoparticles known as nanomicelles, which were glucosylated (linked with sugar molecules). They then injected these particles into mice afflicted with Alzheimer's disease, over the course of 10 weeks. The research team not only found that the injections reduced the amounts of amyloid beta peptides in the brain, but that there was also a reduction in size and density of the plaques that did wind up forming. What's more, they also found that the treated mice had better learning and spatial memory skills than the untreated mice, which means the treatment might not only slow the disease, but temper its symptoms as well. Of course

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