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IPFS News Link • Science, Medicine and Technology

Weight-loss injectable could replace bariatric surgery knife

03-31-2023 • arclein

When bariatric surgery such as gastric bypass and sleeve gastrectomy are conducted, they not only result in a smaller overall stomach area ?" which effectively reduces the amount of food someone can eat ?" they also create biochemical changes in the body. Most significantly, they change the way the gut secretes two hormones known as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). These hormones help ramp down a person's appetite, keep blood sugar levels normal, and signal fullness. While drugs exist that can mimic GLP-1, they often have unpleasant side effects such as nausea and other forms of gastric distress, that can lead to their discontinuation. They also work on only GLP-1 receptors, ignoring the potential benefits of activating PYY receptors as well.

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Reported By robert klein

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