Here's a roundup of some of the stranger reactions.
1) Obama's base didn't want this
MSNBC anchor and former Republican Congressman Joe Scarborough (FL) suggested that killing bin Laden required Obama to defy his base and his beliefs.
"I think Republicans should stand up and certainly salute Barack Obama for making some — again, for making some very tough choices that his own base did not want him to make," Scarborough said. "That takes courage, that takes leadership, and we saw the results of that courage and leadership saying no to his own base yesterday."
Scarborough added that for Obama, this required "going against his own ideological leanings" -- even though Obama vowed as a candidate, "We will kill bin Laden. We will crush al-Qaeda."
2) 'Welcome to hell, bin Laden'
Bush's ex-adviser Karl Rove had similarly vivid remarks when discussing his reaction to the news.
"I had a sweet taste of revenge," Rove said on Fox News. "I'm glad he's rotting in hell, which is exactly where I think he is this morning."