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News Link • Drugs and Medications

Gray Matter: Extracting Bismuth From Pepto-Bismol Tablets

•, By Theodore Gray
 Most modern medicines are carefully synthesized organic molecules so potent that each pill contains only a few milligrams of the active ingredient. Pepto-Bismol is a fascinating exception, both because its active ingredient is bismuth, a heavy metal commonly used in shotgun pellets, and because there is a lot of it in each dose. So much, in fact, that I was able to extract a slug of bismuth metal from a pile of pink pills.
One two-pill dose of Pepto-Bismol contains 262 milligrams (more than a quarter of a gram) of bismuth subsalicylate, and about an eighth of that weight is bismuth. It’s not just bits of ground-up bismuth metal, though. The bismuth is combined chemically with salicylate, an organic molecule. To get bismuth metal, you have to reduce it chemically, the way iron ore has to be reduced to make iron metal.

I tried reducing Pepto-Bismol by heating it with charcoal, the same method used to reduce iron ore, but that didn’t work very well. All I got was crumbly slag. Fortunately, I found a better procedure with an assist from science-experiment website, which recommends isolating the bismuth by reaction with aluminum in an acid solution. This way requires only muriatic acid (found in the paint department at my local hardware store) and aluminum foil (found in my kitchen).

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