According to a group of UCLA researchers, the key to happiness lies in a certain neurotransmitter called hypocretin. When study subjects were happy, hypocretin levels soared. When the were sad, hypocretin levels decreased.
This has implications for both depression treatment and the study of narcolepsy, as the sleep disorder and depression often go hand in hand. The study, from last week's Nature Communications, looked at the release of two peptides (chemical compounds with two or more bonded amino acids) in the brain -- MCH, or melanin-concentrating hormone, and hypocretin. Hypocretin levels increase when we're waking up, while MCH levels increase during the onset of sleep.
To examine the relationship between hypocretin, depression and narcolepsy, researchers followed eight epileptic hospital patients whose brains were already being monitored by implanted electrodes. They measured the release of hypocretin and MCH while the patients watched TV, talked to hospital staff and their families, underwent clinical testing and slept. The patients rated their moods every hour in a questionnaire.