The paper describes how all of these effects could work together, and with other variables, trigger health problems in humans, including debilitating diseases like gastrointestinal disorders, diabetes, heart disease, obesity, Parkinson’s and Alzheimer’s disease.
Glyphosate impairs the cytochrome P450 (CYP) gene pathway, which creates enzymes that help to form and also break down molecules in cells. There are myriad important CYP enzymes, including aromatase (the enzyme that converts androgen into estrogen) and 21-Hydroxylase, which creates cortisol (stress hormone) and aldosterone (regulates blood pressure). One function of these CYP enzymes is also to detoxify xenobiotics, which are foreign chemicals like drugs, carcinogens or pesticides. Glyphosate inhibits these CYP enzymes, which has rippling effects throughout our body.
Because the CYP pathway is essential for normal functioning of various systems in our bodies, any small change in its expression can lead to disruptions. For example, humans exposed to glyphosate have decreased levels of the amino acid tryptophan, which is necessary for active signaling of the neurotransmitter serotonin. Suppressed serotonin levels have been associated with weight gain, depression and Alzheimer’s disease.
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