Targeted drug-delivery vehicles (e.g., liposomes, nano-particles) have often been proposed in an effort to reduce the side effects of such drugs and improve their overall efficacy for treating genetic, viral and malignant diseases. Three main considerations must be addressed when designing any such delivery system: It should be biocompatible; bioavailable; and highly selective to its specific target. Targeting may be improved by conjugating drug carrying vehicles with targeting moieties that substantially improve their selectivity. For example, antibodies, proteins etc. have been incorporated into nano-sized drug-carriers made from polymeric particles, micelles or liposomes, yet their relatively short circulation time and the complexity of their production render them too costly and inefficient.
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