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In 2008, a University of Minnesota study showed that the original cells from a rat heart could be completely flushed out of the heart's external structure in a process called decellularization, then replaced by newborn rat cells to regenerate a working heart. A similar process has now allowed Pitt scientists to grow working human heart tissue within the decellurized structure of a mouse heart.
Using various enzymes and special cleansing detergents, the researchers stripped a mouse heart of all its cells to create a scaffold for induced pluripotent stem cells (iPS cells), adult human cells that are reprogrammed to act like embryonic cells. They treated the iPS cells taken from a skin biopsy to become multipotential cardiovascular progenitor (MCP) cells, the precursor cells that can become any of the three types of cells found in the heart.
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