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Scientists identify major cause of age-related memory loss


In a study published August 28 in the online edition of the journal Science Translational Medicine, a team of researchers from the Columbia University Medical Center – led by Nobel laureate Eric R. Kandel, M.D. – describe their discovery of a protein deficiency in the hippocampus that contributes significantly to a reversible form of age-related memory loss.  The protein at the center of the study, which used postmortem human brain cells in mice as research subjects, is called RbAp48.  The results of the study offer the most promising evidence to-date that age-related memory loss and Alzheimer’s are distinct brain conditions.

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