Then he analyzed liposomal C to discover that, although IV C delivers more vitamin C into the bloodstream than orally ingesting vitamin C, not all of it permeated tissue cells.
It's estimated that maybe 20% of IV vitamin C volume gets into cells, while 90% of liposomal C permeates tissue on a cellular level. Vitamin C is water soluble, and cell walls are fatty. Liposomal C is a lipid (fatty substance) encapsulated on a molecular level.
This enables higher oral doses vitamin C to permeate cells while not overwhelming bowel thresholds.