His death was confirmed in a statement by his publicist Don Murry Grubbs, the Tennessean reported.
Doctors determined that the country singer died after suffering a hemorrhagic stroke, his publicist revealed.
The Grammy winner had suffered a mild stroke back in January 2010 and had a heart pacemaker implanted in 2013 but continued to perform.
He had also been successfully treated for prostate cancer in 2001.
The Grand Ole Opry member is survived by his wife, Hazel, and son Charlie Daniels, Jr.