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IPFS News Link • Pandemic

Supercomputer Model Identifies Pathways and Possible Weaknesses of COVID-19

•, by Brian Wang

 The Bradykinin storm cause gel to form in the lungs and the blood vessels to leak. The same analysis identifies about ten interventions to reduce the severity of COVID-19. An easy precaution is to take some Vitamin D. This will not prevent COVID-19 but might help reduce the chance for a severe case and reduce the severity of it.

Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow wrote the researchELife – A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

The data shows COVID-19 increases production of hyaluronic acid (HLA) in the lungs. HLA is often used in soaps and lotions for its ability to absorb more than 1,000 times its weight in fluid. When it combines with fluid leaking into the lungs, the results are disastrous: It forms a hydrogel, which can fill the lungs in some patients. This becomes like trying to breathe through Jell-O.

The renin–angiotensin system (RAS) controls many aspects of the circulatory system, including the body's levels of a chemical called bradykinin, which normally helps to regulate blood pressure. According to the team's analysis, when the virus tweaks the RAS, it causes the body's mechanisms for regulating bradykinin to go haywire. Bradykinin receptors are resensitized, and the body also stops effectively breaking down bradykinin.