A top U.S. general in Afghanistan was fired Friday for making disparaging remarks about Afghan President Hamid Karzai and his government.

Maj. Gen. Peter Fuller, deputy commander of the NATO training mission in Afghanistan, made the remarks in an interview with Politico that was published Thursday.

Fuller told Politico that major players in the Afghan government are "isolated from reality." Fuller reacted angrily to claims from Karzai that Afghanistan would side with Pakistan if it were to go to war with the United States.