(NASA needs the Russians to get to the ISS and to launch things but European allies can freeze in the dark. Take that, Europeans, it's for your own good! "You can't… ask for a bigger U.S. military commitment… while… oppose nonmilitary coercive measures").
The effect of anti-Russia sanctions since 2014 is that Europe has likely suffered more than Russia and certainly more than the USA; Russia has used the sanctions (and its counter sanctions) to increase domestic production (see below) whereas Europe has just lost markets. Well, we'll find out whether Europe has the feet to stand on that Merkel thinks it has.
Russia has many ways to respond and, as Jeffrey Carr has pointed out, Congress has shown it where to hit hardest.