Chaos is unfolding in the Iran war after multiple US aircraft crashes were reported Friday, as an urgent search-and-rescue mission continues for a downed American pilot behind enemy lines.

An American F-15E Strike Eagle was shot down over Southern Iran earlier Friday, ejecting two pilots into enemy territory.

One of the American fighter pilots has been rescued by US forces, two US officials have confirmed. A second crew member remains missing, CBS News reported. 

Donald Trump has been briefed on the rescue mission, the White House confirmed. In a brief phone interview, Trump declined to discuss details of the search and rescue operation. 

When asked by NBC News reporter Garrett Haake if the pilot crashes will affect negotiations with Iran, the President responded: 'No, not at all. No, it's war. We're in war, Garret'

It marked the first time a US jet has been downed by enemy fire since the start of the war 35 days ago. 

Meanwhile, Newsmax reported that a US Black Hawk was hit by enemy fire while conducting rescue operations for the pilots. The crew is reportedly accounted for and is safe. 

An A-10 Warthog combat plane crashed in the Persian Gulf near the Strait on Hormuz on Friday but the pilot was rescued, according to the New York Times. It is unclear how the plane went down. 

It comes as Iranian state media urged civilians to capture the pilots on the Strike Eagle, with a 'reward' offered by the Islamic regime. 

Israel media reported that the missing airmen has likely sent out his emergency location signal out to the rescue team. 

Footage has emerged of tribesman shooting at what appears to be an Air Force HC-130J Combat King II, a specialized search and rescue plane.

Separate videos purported to show a US KC-130 refueling tanker and two HH-60 Pave Hawk search and rescue helicopters.

Iranian media released images showing debris as well as ejector seats from the downed F-15E, which costs approximately $100 million.

An anchor on Iranian state media urged local residents in Southern Iran to hunt down and hand over the 'enemy pilot' to regime authorities. 

The local TV channel is based in Kohkilouyeh and Boyer-Ahmad province, an intensely rural and mountainous region, the Associated Press reported. 

Viewers were also told to 'shoot them if you see them,' referring to US aircrafts flying low in the region in an apparent search for the crew members.