It has surprised me how adaptable tumours can be. I don't want to sound too depressing about this, but I think ?" given the almost infinite possibilities in which a tumour can evolve, and the very large number of cells in a late-stage tumour, which could be several hundred billion cells ?" then achieving cures in all patients with late-stage disease is a formidable task. Study reveals cancer's 'infinite' ability to evolve, BBC, 12 April 2023 So, what is at the root of this problem? According to a series of recent TRACERx results