A new class of gel-based sponges can be molded to any shape, soak up
drugs or stem cells, shrink down and be injected into the body, where
they inflate to their original size and leak out their contents. They
work kind of like those “dinosaur egg” sponges you can get at museum
gift shops, where contact with water inflates little pellets into soft
dino-shapes. Only they’ll be inside your body.
Bioengineers at Harvard and Caltech designed the sponges, which are primarily made from
alginate, a gel made from algae. They can be molded into any shape or
size and contain large pores, which allow liquids and large molecules to
pass through. The pores can also hold cells, proteins and
small-molecule drugs, which can then pass into the body when the
alginate starts to break down.
They could be promising new tissue scaffolds at sites of injury or
infection, according to David J. Mooney, a bioengineering professor at
Harvard’s School of Engineering and Applied Sciences. They could
transplant stem cells, bulk up tissue that’s been lost or degenerated,
or even transplant immune cells, Mooney said. Because they can be built
to any shape--the team made hearts, stars and squares--they could
theoretically be used for any size or shape area in the body.