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IPFS News Link • Science, Medicine and Technology

Tiny cellular bubbles enable delivery of Parkinson's drugs straight to the brain

• gizmag.com

These extremely potent antioxidants can tackle neuron-killing inflammation with an effectiveness unparalleled by small molecule drugs. But there's a problem, they are big. So big that getting them through the blood-brain barrier for delivery straight to the brain is nearly impossible. But researchers have now discovered that loading them into tiny, naturally occurring bubbles allows them to sneak past the brain's defenses, pointing to the possibility of improved treatments for such conditions.

Led by Dr Elena Batrakova at the University of North Carolina, scientists extracted what are called exosomes from human immune cells. These microscopic bubbles have a role to play in conditions like AIDS and cancer, as they are hijacked to facilitate the spread of diseases around the body. In this case, the researchers were able to load them with catalase with the intent of sneaking the protein into the brain to battle the destructive molecules that cause inflammation.


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