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The team at the Institute of Cancer Research, in London, say men could soon be offered genetic screening in a similar way to breast cancer in women.
They have shown 14 separate mutations can greatly increase the odds of aggressive prostate cancers, which could form the basis of a test.
Prostate Cancer UK said such testing could "revolutionise" care for men.
Prostate cancer is the commonest cancer in men in many countries, including the UK - where more than 40,000 people are diagnosed each year.
But not every patient has, or needs, invasive therapy that results in severe side-effects.
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