The flyby of the Juno spacecraft, surveilling the 10,000-mile-wide (16,000-kilometer-wide) storm, is scheduled for 9:55 pm Monday (0155 GMT Tuesday).

"Jupiter's mysterious Great Red Spot is probably the best-known feature of Jupiter," said Scott Bolton, principal investigator of Juno from the Southwest Research Institute in San Antonio.

"This monumental storm has raged on the solar system's biggest planet for centuries."

The storm looks like a churning red knot on the planet's surface. It has been monitored since 1830, and may have existed for more than 350 years, the US space agency said.

Juno, which earlier this month marked its first year in orbit of the gas giant, will offer "humanity's first up-close and personal view of the gigantic feature," NASA said in a statement.