Hundreds of thousands of troops serving in Afghanistan and Iraq have sustained TBIs in recent decades, and these injuries are suspected of playing a role in the high rates of depression and suicide seen among military veterans. With mainstream treatment options not fully effective for all veterans, researchers have sought therapeutic alternatives. Ibogaine has gained notoriety in scientific communities for its potential to treat opioid and cocaine addiction, because it increases signaling of several important molecules within the brain, some of which have been linked to drug addiction and depression.