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An Unexpected Discovery in the Brains of Autistic Children

•, By Greg Miller
 Scientists have found countless clues, but so far they don’t quite add up. The genetics is complicated. The neuroscience is conflicted.
Now, a new study adds an intriguing, unexpected, and sure-to-be controversial finding to the mix: It suggests the brains of children with autism contain small patches where the normally ordered arrangement of neurons in the cerebral cortex is disrupted. “We’ve found locations where there appears to be a failure of normal development,” said Eric Courchesne, a neuroscientist at the University of California, San Diego and an author of the study, which appears today in the New England Journal of
 “It’s been really difficult to identify a lesion or anything in the brain that’s specific and diagnostic of autism,” said Thomas Insel, director of the National Institute of Mental Health, one of several agencies that funded the project. The new study is notable because it applies sophisticated molecular labeling methods to postmortem tissue from people with autism who died as children, which is incredibly hard to come by, Insel says.

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