Krill oil reduced oxidative stress and activated natural antioxidant enzymes, helping cells protect themselves from damage caused by fat overload

Krill oil improved insulin sensitivity by lowering insulin levels and boosting adiponectin, a hormone that helps your body burn fat and use sugar properly

Unlike fish oil, krill oil's omega-3s are bound to phospholipids, making them easier to absorb and more effective at targeting inflammation and fat buildup

Krill oil outperformed a prescription cholesterol drug in several key markers and did so without side effects, offering a safer way to restore metabolic health

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Fatty liver disease is one of the earliest, and most overlooked, signs that your metabolism is in trouble. It often shows up without warning, quietly damaging your liver while setting the stage for insulin resistance, obesity and heart disease. And yet, most people don't realize they have it until it's advanced. The good news? Research is uncovering targeted, natural solutions that help reverse this trend. One of the most promising involves krill oil, a source of omega-3s many are missing.

Krill oil doesn't just mask the symptoms, it helps reset the biological drivers of fat accumulation, inflammation, and oxidative stress at their core. Let's explore how this unique marine oil, different from standard fish oil, helps protect your liver, optimize cholesterol metabolism, and support antioxidant defenses from the inside out.

Krill Oil Targets Fat, Inflammation, and Oxidative Stress at the Same Time

A 2024 study published in Nutrients examined the effects of krill oil supplementation on mice with diet-induced obesity and metabolic dysfunction.1 The goal was to see if krill oil could reduce fat buildup in the liver, optimize cholesterol, and lower oxidative stress, all key drivers of fatty liver disease and cardiovascular risk. Researchers also explored whether the compounds in krill oil interfere with specific enzymes that promote cholesterol synthesis and fat storage.

• The animals used in the study were fed a high-fat diet to simulate obesity and metabolic damage —The mouse model was designed to mirror what happens in humans who eat high-fat, high-calorie diets. These animals gained weight, accumulated visceral and liver fat, and developed blood markers tied to poor metabolic health.

Krill oil was given at a dose of 400 milligrams (mg) per kilogram (kg) daily for 60 days. Researchers tracked changes in blood cholesterol, triglycerides, liver enzyme levels, and oxidative stress markers to evaluate krill oil's effects.